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KMID : 0361020010440070718
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 7 p.718 ~ p.722
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Expression Pattern of Trefoil Factor Family Peptides mRNA in Human Nasal Mucosa
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이승훈/Seung Hoon Lee
김태훈/김형진/나홍식/팽재필/이흥만/이상학/Tae Hoon Kim/Hyung Jin Kim/Hong Shik Na/Jae Phil Pang/Heung Man Lee/Sang Hag Lee
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Abstract
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Background and Objectives : Trefoil factor family (TFF) peptides are typical secretory products of gastrointestinal mucus epithelia. Three TFF-peptides exist in human : TFF1 (formerly pS2), TFF2 (formerly hSP), TFF3 (formerly hPl.B/hITF). They
act
as
link peptides and influence the rheological properties of mucous gels. The combined actions of TFF peptides and mucins have been shown to provide significant protection to mucosal surfaces. In this respect, TFF peptides may play a key role for
the
maintenance of the surface integrity of nasal mucosa. Materials and Methods : The present study aimed to investigate the expression of TFF peptides mRNA in human inferior turbinate mucosa using a reverse transcription polymerase (RT-PCR) and in
situ
hybridization. Results : TFF1 and TFF3 mRNA were detected in the human turbinate tissues. In contrast, TFF2 mRNA was not expressed in any samples. By in situ hybridization, TFF1 and TFF3 mRNA were predominantly localized in the epithelial cells
and
the
submucosal glandular epithelium. Conclusion : These data suggest that nasal epithelia and submucosal glands may secrete TFF1 and TFF3, contributing to the stabilization of the mucous lining of human nasal mucosa.
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KEYWORD
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